Item no. |
CSB-PA002069LC01HU-50ug |
Manufacturer |
Cusabio
|
Amount |
50ug |
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Conjugate/Tag |
FITC |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
HT005 antibody; all trans retinoic acid inducible RING finger antibody; Ari 2 antibody; Ari-2 antibody; ARI2 antibody; ARI2_HUMAN antibody; Ariadne 2 antibody; Ariadne 2 protein homolog antibody; ariadne homolog 2 (Drosophila) antibody; ariadne homolog 2 antibody; Ariadne RBR E3 ubiquitin protein ligase 2 antibody; ARIH 2 antibody; Arih2 antibody; E3 ubiquitin protein ligase ARIH2 antibody; E3 ubiquitin-protein ligase ARIH2 antibody; protein ariadne 2 homolog antibody; Protein ariadne-2 homolog antibody; Triad 1 antibody; TRIAD1 antibody; Triad1 protein antibody; UIP48 antibody, E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein), ARIH2, ARI2 TRIAD1 |
Similar products |
ARIH2, E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein), ARI2 TRIAD1 |
Available |
|
Immunogen Species |
Human |
UniprotID |
O95376 |
Immunogen |
Recombinant Human E3 ubiquitin-protein ligase ARIH2 protein (43-360AA) |
Applications info |
ELISA |
Background |
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). |
Conjugate |
FITC |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Epigenetics and Nuclear Signaling, Cell biology |
Initial Research Areas |
Epigenetics and Nuclear Signaling |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.