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Anti Protein S100-A1 (S100 Alpha) pAb (Rabbit, Affinity Purified)

Anti Protein S100-A1 (S100 Alpha) pAb (Rabbit, Affinity Purified)

Item no.

CAC-ACC-PA002

Manufacturer

Cosmobio

Amount

50 ug

Category

Type

Antibody Monoclonal

Format

Affinity Purified

Applications

WB, IF, IP, IHC, ICC, ELISA

Specific against

Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Pig (Porcine, Sus scrofa domesticus), Cattle (Bovine)

Host

Rabbit

Isotype

IgG

ECLASS 10.1

42030590

ECLASS 11.0

42030590

UNSPSC

12352203

Available

Manufacturer - Applications

WB, IP, ELISA, ICC, IF, IHC(p)

Manufacturer - Category

Research Area/Development/Angiogenesis/Primary Antibodies; Research Area/Development/Brain & CNS/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Organs & Organ Systems/Cardiovascular System/Primary Antibodies; Antibodies/Signal Transduction/Abs For Paraffin Embedded Tissue; Antibodies/Abs For Paraffin Embedded Tissue/Signal Transduction; Research Area/Development/Angiogenesis/Abs For Paraffin Embedded Tissue; Research Area/Development/Brain & CNS/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Signal Transduction/Abs For Paraffin Embedded Tissue; Research Area/Organs & Organ Systems/Cardiovascular System/Abs For Paraffin Embedded Tissue; Antibodies/Signal Transduction/Primary Antibodies; Antibodies/Primary Antibodies/Signal Transduction; Research Area/Systemic Physiology/Calcium Transport & Homeostasis/Abs For Paraffin Embedded Tissue; Research Area/Systemic Physiology/Calcium Transport & Homeostasis/Primary Antibodies; Research Area/Cell Types/Chondrocytes/Abs For Paraffin Embedded Tissue; Research Area/Cell Types/Chondrocytes/Primary Antibodies; Research Area/Cell Types/Cardiomyocytes/Abs For Paraffin Embedded Tissue; Research Area/Cell Types/Cardiomyocytes/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Sarcoplasmic Reticulum/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Sarcoplasmic Reticulum/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Mitochondria/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Mitochondria/Primary Antibodies

Maker

CAC

Antigen/Source

Purified S100-alpha protein fromhuman pectoral muscle cells.

Description

Background
Neurodegenerative diseases such as Alzheimer' s disease and Parkinson' s disease have been increasing rapidly and have become a serious social problem. In recent years, new causative genes have been discovered for amyotrophic lateral sclerosis (ALS) and other intractable neurological diseases opening new avenues for research on pathogenesis. It has been suggested that aggregation and accumulation of specific proteins cause neurotoxicity and the formation of lesions, but the onset and progression mechanisms are still unclear. Neuropathological diagnostic and experimental model biomarkers are needed for drug construction, drug discovery, and therapeutic development.
The S100 protein is a low-molecular-weight, acidic and calcium binding protein that in functional form exist in dimers. S100 has two subunits: S100-alpha (94 aa; human chromosome 1) and S100-beta (92 aa; human chromosome 21) that forms as either homodimers (alpha-alpha known as S-100a(0) or beta-beta known as S-100b) or as heterodimers (known as S-100a) of ~21 kDa. S100-alpha and -beta chains show ~58% sequence identity and are both highly conserved among species. S100-alpha was originally believed to be localized to the CNS, but studies have shown it to be found in numerous tissues including cardiac, skeletal and vascular smooth muscle cells.

Applications

Western Blotting (WB): 0.1 µ g/ml
Immunoprecipitation (IP) : 5 µ g/ml
Enzyme-linked immunosorbent assay (ELISA): assay dependent
Immunocytochemistry (ICC) : 1:50 - 1:200
Immunofluorescence (IF): 1 µ g/ml
Immunohistochemistry (Paraffin) (IHC (P)): 1 µ g/ml

Product description

Package Size	50 µ g
Form	Liquid (0.1M NaPB, pH7.0, 20 mg/ml BSA, 0.1% Sodium Azide (NaN3) added)
Purity	Affinity Purified
Host	Rabbit Polyclonal
Immunogen	Purified S100-alpha protein from human pectoral muscle cells
Specificity	S100-alpha protein
Cross Reactivity	Bovine, Human, Mouse, Porcine, Rat
Subclass	IgG
Storage	Store below -20° C. Avoid freeze-thaw cycles.
Clonality	Polyclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

CAC-ACC-PA002.pdf

CAC-ACC-PA002-datasheet.pdf

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Amount: 50 ug

available

Delivery expected until 1/17/2025

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