TNKS1 Polyclonal Antibody

Catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor., May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length., PTM:ADP-ribosylated (-auto)., PTM:Phosphorylated on serine residues by MAPK kinases upon insulin stimulation., Contains 1 PARP catalytic domain., Contains 1 SAM (sterile alpha motif) domain., Contains 15 ANK repeats., subcellular location:Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1., subunit:Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2., tissue specificity:Ubiquitous; highest levels in testis.,

Synthesized peptide derived from part region of human protein

1 mg/ml