Manufacturer |
Bioworld Technology, Inc
|
Category |
|
Type |
Antibody Primary |
Specific against |
Human, Mouse, Rat |
Applications |
WB, FC, IF, IHC, ICC |
Amount |
100ul |
Host |
Rabbit |
Item no. |
BS91265-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Alias |
SNX1, HsT17379, MGC8664, SNX 1, SNX 1a, Snx1, SNX1, SNX1A, Sorting nexin 1, Sorting nexin 1A, Sorting nexin-1, Vps5, |
Swiss-Prot |
Q13596(Human) Q99N27(Rat) |
Application_all |
WB:1:1, 000-1:2, 000 ICC/IF:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 |
Background |
Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking. SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor. SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain. These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases. These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes. The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors. |
Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Purification And Purity |
ProA affinity purified |
Storage And Stability |
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles. |
Specificity |
SNX1 polyclonal antibody detects endogenous levels of SNX1 protein. |
BiowMW |
63 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
Recombinant protein within human SNX1 aa 50-250. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.