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Lamin A/C (phospho-S22) polyclonal antibody

Lamin A/C (phospho-S22) polyclonal antibody

Item no.	BS74023-100
Manufacturer	Bioworld Technology, Inc
Amount	100ul
Category	Neuroscience Neural Lineage Markers Antibodies Cell Biology Cytoskeleton Immunoprecipitation Western Blot Primary Antibodies Intermediate filaments
Type	Antibody Primary
Applications	WB, IP
Specific against	Human, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C
Available
Swiss-Prot	P02545
Application_all	WB 1:500 - 1:2000 IP 1:50 - 1:100
Background	Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage And Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	Lamin A/C (phospho-S22) polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser22.
BiowMW	ca. 69, 78 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	A phospho specific peptide corresponding to residues surrounding S22 of human LMNA

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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