EHD4 polyclonal antibody

Q9H223

Eps15 homology domain (EHD)-containing proteins function in the exit of receptors and other membrane proteins from the endosomal recycling compartment. EHD4 (Eps15 homology domain-containing protein 4), also known as PAST4 or Pincher, belongs to a subfamily of the EHD protein family that includes the closely related proteins EHD1, EHD2 and EHD3. EHD4 is predominantly expressed in pancreas and heart localizing to vesicular and tubular structures in the cell. It contains an EH domain as well as a calcium binding EF hand. EHD4 is believed to function in transport from the early endosome to the endocytic recycling compartment. In addition, EHD4 is capable of binding lipids via its EH domain. Loss of EHD4 can lead to retention of transferrin in peripheral compartments suggesting that EHD4 regulates the transport of transferrin out of the early endosome.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

EHD4 polyclonal antibody detects endogenous levels of EHD4 protein.

For research use only, not for use in diagnostic procedure.