Item no. |
BS61266-100 |
Manufacturer |
Bioworld Technology, Inc
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Serine/threonine-protein kinase TNNI3K (EC:2.7.11.1), Cardiac ankyrin repeat kinase, Cardiac troponin I-interacting kinase, TNNI3-interacting kinase, TNNI3K, CARK |
Similar products |
TNNI3K |
Available |
|
Swiss-Prot |
Q59H18 |
Application all |
WB: 1:500ca.1:1000 |
Background |
TNNI3K (TNNI3-interacting kinase), also known as CARK (Cardiac ankyrin repeat kinase), is a 936 amino acid serine/threonine-protein kinase that is highly expressed in heart. Overexpression of TNNI3K leads to improved cardiac function by enhancing beating frequency and increasing contractile force and epinephrine response. TNNI3K suppresses phosphorylation of cardiac troponin I and p38/JNK-mediated apoptosis, therefore protecting the myocardium from ischemic injury. Administration of TNNI3K to mice with myocardial infarction improves cardiac performance and attentuates ventricular remodeling, suggesting that TNNI3K could be a promising target in the treatment of cardiac diseases. There are four isoforms of TNNI3K that are produced as a result of alternative splicing events. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
TNNI3K pAb detects endogenous levels of TNNI3K protein. |
WB |
Western blot (WB) analysis of TNNI3K pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate |
BiowMW |
ca. 78 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
Serine/threonine-protein kinase TNNI3K (EC:2.7.11.1), Cardiac ankyrin repeat kinase, Cardiac troponin I-interacting kinase, TNNI3-interacting kinase, TNNI3K, CARK |
Immunogen |
A synthetic peptide corresponding to residues in Human TNNI3K. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.