Item no. |
ARP-01-2702 |
Manufacturer |
American Research Products
|
Amount |
200 ul |
Category |
|
Type |
Antibody Monoclonal |
Applications |
WB, IF, ELISA |
Clone |
AT21S5 |
Specific against |
Human |
Host |
Mouse |
Isotype |
IgG2b kappa |
Citations |
Shahrokni A, et al., (2009) Clin Colorectal Cancer 8(4):231-4 Henriquez-Hernandez LA, et al., (2009) Oncol Rep 22(6):1425-33 Colavito D, et al., (2009) Cancer Chemother Pharmacol 64(6):1195-200 |
NCBI |
NP_001062 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
HST422, TMS, TS, d TMP synthase, EC 2.1.1.45, MGC88736, Thymidylate synthase, Thymidylate synthetase, Tsase, TYMS, TYMS protein, Tyms thymidylate synthetase, |
Available |
|
Description |
The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dMTP) is an essential step for the formation of thymine nucleotides. This process is catalyzed by thymidylate synthase (TS or TYMS). TYMS is an intracellular enzyme that provides the sole de novo source of thymidylate in activity highest proliferating cells. Being the exclusive source of dTMP, TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head and neck. TS expression may be useful in predicting overall patient survival, but the prognostic value of TS expression continues to be a subject of investigation for different types of cancers. |
Immunogen |
Recombinant TYMS (1-313aa) purified from E. coli |
Form |
Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
Working Dilution |
Optimal dilution should be performed by user. |
Storage |
Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
Concentration |
0.1 mg/ml |
Interest Field |
Cancer |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.