Item no. |
AP52595 |
Manufacturer |
Abcepta
|
Amount |
100 ul |
Category |
|
Type |
Antibody Primary |
Applications |
WB, IHC |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
MEF2C, Myocyte-specific enhancer factor 2C |
Available |
|
Primary Accession |
Q06413 |
Antigen Type |
synthetic peptide |
Application |
WB, IHC |
Bio Background |
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. |
Bio References |
Leifer D., et al.Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).McDermott J.C., et al.Mol. Cell. Biol. 13:2564-2577(1993).Infantino V., et al.Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.Bechtel S., et al.BMC Genomics 8:399-399(2007).Schmutz J., et al.Nature 431:268-274(2004). |
Clonality |
Polyclonal |
Gene ID |
4208 |
Gene Name |
|
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Legend image 1 |
Western blot analysis of extracts from 3T3 cells, treated with starved (24hours), using MEF2C (Phospho-Ser396) antibody. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Western blot analysis of extracts from cos-7 cells (Lane 2), using MEF2C (Phospho-Ser396) Antibody. The lane on the left is treated with synthesized peptide. |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
Immunohistochemistry analysis of paraffin-embedded human brain tissue using MEF2C (Phospho-Ser396) antibody. |
Type image 3 |
IHC |
Dilution image 3 |
1:50~100 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.