Item no. |
AP1442-20uL |
Manufacturer |
Abclonal
|
Amount |
20 uL |
Category |
|
Type |
Antibody Monoclonal |
Applications |
WB, IF, ICC, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Conjugate/Tag |
Unconjugated |
Purity |
Affinity purification |
Sequence |
RHSFS |
NCBI |
ERN1 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
IRE1; IRE1P; IRE1a; hIRE1p |
Available |
|
Background |
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. |
Route |
Synthetic Peptide |
Manufacturers Category |
Phosphorylated Antibodies |
Immunogen |
A synthetic phosphorylated peptide around S724 of human IRE1(NP_001424.3). |
Storage |
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Recommended Dilution |
WB, 1:1000 - 1:5000|IF/ICC, 1:50 - 1:200|IHC-P, 1:50 - 1:200 |
Protein Size |
110kDa |
Manufacturers Research Area |
Signal Transduction, Kinase, Cell Biology Developmental Biology, Apoptosis, Neuroscience, Neurodegenerative Diseases |
Gene Symbol |
ERN1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.