Comparison

mAb anti-Amyloid Beta Peptide 42

Item no. ANOG-MO-M40093B-0.1mg
Manufacturer Anogen
Amount 0.1mg
Category
Type Antibody Monoclonal
Applications ELISA, NT, Dot
Clone CA10 C11
Specific against Human, Mouse, Rat
Host Mouse
Isotype IgG2b kappa
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Available
Description
Mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42)
Target Protein
C-terminal of amyloid beta peptide 42
Immunogen
KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Abeta42
Specificity
This antibody recognizes the C-terminal sequence (MVGGVVIA) of Abeta42 and full length Abeta42.
Purification
Protein G affinity purified
Cross Reactivity
The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is about 5% in ELISA.
Myeloma
Sp2/0-Ag14
Light chain
Kappa
Background
Amyloid beta peptide 42 (Abeta42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Abeta42 and Abeta40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Abeta42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Abeta42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Abeta42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Abeta42 oligomer is the cause of the disease.
Formulation
Lyophilized from a solution in 0.01M PBS, pH 7.2
Reconstitution
Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Research Area
Neurological Disorder
Storage
Store at -20oC

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.1mg
Available: In stock
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