Anti-GPR84 (extracellular)-FITC

Antibodies

Antibodies

Fluorescein isothiocyanate (FITC).

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder

G-protein coupled receptor 84, Inflammation-related G-protein coupled receptor EX33 - A Rabbit Polyclonal Antibody to GPR84 Conjugated to the Fluorescent Dye FITC

Human - 14/15 amino acid residues identical; mouse, rat - 13/15 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

1 mg/ml

2nd extracellular loop

Human

41116161

GPR84 is an orphan G-protein coupled receptor (GPCR) activated by micromolar concentrations of medium-chain fatty acids (MCFAs). MCFAs that activate GPR84 are usually with carbon chain lengths of 9-14, which couples primarily to a pertussis toxin (PTX)-sensitive Gi/o pathway. The most potent agonists of GPR84 includes decanoic acid, undecanoic acid and lauric acid. GPR84 demonstrates an important role in inflammation, immunity, and cancer1-3.GPR84 is predominantly expressed in immune system-related tissues and cells, such as bone marrow, spleen, lung, lymph nodes and brain microglia, T-cells, macrophages and glial cells. Its expression is also detected in adipocytes.Studies have shown that GPR84 activation in murine macrophage-like cell line results in high levels of LPS-stimulated IL-12 p40 production. In addition, GPR84 knockout mice display increased Th2 cytokine production1-3.