Item no. |
ABC-AW5646-U100 |
Manufacturer |
Abcepta
|
Amount |
100 ul |
Category |
|
Type |
Antibody Primary |
Applications |
WB, IHC-P |
Specific against |
other |
Host |
Mouse |
ECLASS 5.1 |
32160702 |
ECLASS 6.1 |
32160702 |
ECLASS 8.0 |
32160702 |
ECLASS 9.0 |
32160702 |
ECLASS 10.0.1 |
32160702 |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
RAB11A, RAB11, Ras-related protein Rab-11A, YL8, Rab-11 |
Available |
|
Primary Accession |
P62491 |
Antigen Type |
Recombinant Protein |
Application |
IHC-P, WB |
Bio Background |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. |
Bio References |
Drivas G.T., et al.Oncogene 6:3-9(1991).Zahraoui A., et al.Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.Gromov P.S., et al.FEBS Lett. 429:359-364(1998).Puhl H.L. III, et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.Ebert L., et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. |
Clonality |
Monoclonal |
Gene ID |
8766 |
Gene Name |
RAB11A |
Subtitle |
Purified Mouse Monoclonal Antibody (Mab) |
Reactivity |
H, M, Rat |
Legend image 1 |
All lanes : Anti-RAB11A Antibody at1:4000 dilutionLane 1: 293T/17 whole cell lysateLane 2: C2C12 whole cell lysateLane 3: Hela whole cell lysateLane 4: Jurkat whole cell lysateLane 5: PC-12 whole cell lysateLane 6: rat brain lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 24 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:4000 |
Legend image 2 |
AW5646 staining RAB11A in human brain sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:25 |
Other Accession |
P62490; P62492; Q52NJ1; Q5R9M7; P62493; P62494 |
Predicted |
Pig, Rb |
Isotype |
IgG1, k |
Calculated MW |
24394 |
Antigen Region |
1-216 |
Antigen Source |
HUMAN |
Target/Specificity |
This RAB11A antibody is generated from a mouse immunized with a purified recombinant protein of human RAB11A. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.