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TRAF3IP2 Antibody (monoclonal) (M01)

TRAF3IP2 Antibody (monoclonal) (M01)

Item no.	ABC-AT4330a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, IF, IHC, ELISA
Clone	4A3
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6, Adapter protein CIKS, Connection to IKK and SAPK/JNK, Nuclear factor NF-kappa-B activator 1, TRAF3-interacting protein 2, ACT1
Available
Primary Accession	O43734
Antigen Type	Recombinant Protein
Application	WB, IHC, IF, E
Bio Background	This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
Bio References	The adaptor molecule Act1 regulates BAFF responsiveness and self-reactive B cell selection during transitional B cell maturation. Giltiay NV, et al. J Immunol, 2010 Jul 1. PMID 20543113. Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Liu C, et al. Sci Signal, 2009 Oct 13. PMID 19825828. Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling. Li X. Cytokine, 2008 Feb. PMID 18061473. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. Huang F, et al. J Immunol, 2007 Nov 15. PMID 17982039. Identification of genes related to Parkinson's disease using expressed sequence tags. Kim JM, et al. DNA Res, 2006 Dec 31. PMID 17213182.
Clonality	Monoclonal
Gene ID	10758
Gene Name	TRAF3IP2 (HGNC:1343)
Subtitle	Mouse monoclonal antibody raised against a partial recombinant TRAF3IP2.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to TRAF3IP2 on HeLa cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (38.39 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	TRAF3IP2 monoclonal antibody (M01), clone 4A3 Western Blot analysis of TRAF3IP2 expression in Hela S3 NE ( (Cat # AT4330a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Immunoperoxidase of monoclonal antibody to TRAF3IP2 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
Type image 4	IHC
Legend image 5	Detection limit for recombinant GST tagged TRAF3IP2 is approximately 1ng/ml as a capture antibody.
Type image 5	E
Other Accession	BC002823
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	TRAF3IP2 (AAH02823, 451 a.a. ~ 565 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001157753.1; NP_001157755.1; NP_679211.2
	Clone: 4A3
Org Accession	AAH02823
Gene Description	TRAF3 interacting protein 2
Gene Summary	This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 11/8/2024

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