Item no. |
ABC-AT4091a |
Manufacturer |
Abcepta
|
Amount |
100 ug |
Category |
|
Type |
Antibody Primary |
Format |
Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Applications |
WB, IF, IHC, ELISA |
Clone |
5F8 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
AURKA, Aurora kinase A, Aurora 2, Aurora/IPL1-related kinase 1, Serine/threonine-protein kinase 6, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, ARK-1, hARK1, Aurora-related kinase 1, Serine/threonine-protein kinase aurora-A |
Available |
|
Primary Accession |
O14965 |
Antigen Type |
Recombinant Protein |
Application |
WB, IHC, IF, E |
Bio Background |
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. |
Bio References |
1.KIBRA Protein Phosphorylation Is Regulated by Mitotic Kinase Aurora and Protein Phosphatase 1.Xiao L, Chen Y, Ji M, Volle DJ, Lewis RE, Tsai MY, Dong J.J Biol Chem. 2011 Oct 21; 286(42):36304-15. Epub 2011 Aug 30.2.Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation.Lo Iacono M, Monica V, Saviozzi S, Ceppi P, Bracco E, Papotti M, Scagliotti GV.J Transl Med. 2011 Jun 30; 9:100. |
Clonality |
Monoclonal |
Gene ID |
6790 |
Gene Name |
AURKA |
Subtitle |
Mouse monoclonal antibody raised against a partial recombinant STK6. |
Reactivity |
H |
Legend image 1 |
Immunofluorescence of monoclonal antibody to STK6 on HeLa cell. [antibody concentration 30 ug/ml] |
Type image 1 |
IF |
Legend image 2 |
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) . |
Type image 2 |
WB |
Dilution image 2 |
1:500~1000 |
Legend image 3 |
STK6 monoclonal antibody (M01), clone 5F8 Western Blot analysis of STK6 expression in Hela S3 NE ( (Cat # AT4091a ) |
Type image 3 |
WB |
Dilution image 3 |
1:500~1000 |
Legend image 4 |
Immunoperoxidase of monoclonal antibody to AURKA on formalin-fixed paraffin-embedded human prostate. [antibody concentration 6 ug/ml] |
Type image 4 |
IHC |
Legend image 5 |
Detection limit for recombinant GST tagged STK6 is approximately 0.1ng/ml as a capture antibody. |
Type image 5 |
E |
Other Accession |
NM_198433 |
Isotype |
IgG2a Kappa |
Target/Specificity |
AURKA (NP_940835, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
NCBI Accession |
NP_003591.2; NP_940835.1; NP_940836.1; NP_940837.1; NP_940838.1; NP_940839.1 |
|
Clone: 5F8 |
Org Accession |
NP_940835 |
Concentration |
0.5 mg/ml |
Gene Description |
aurora kinase A |
Gene Summary |
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.