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SLC1A2 Antibody (monoclonal) (M07)

SLC1A2 Antibody (monoclonal) (M07)

Item no.	ABC-AT3905a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, ELISA
Clone	1D8
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	EAAT2, SLC1A2, GLT1, Excitatory amino acid transporter 2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2
Available
Primary Accession	P43004
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Bio References	Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. Kantoj?rvi K, et al. Psychiatr Genet, 2010 Jun. PMID 20410850.Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. Saus E, et al. J Psychiatr Res, 2010 Apr 14. PMID 20398908.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease. Tian G, et al. J Neurochem, 2010 May. PMID 20193040.Comparative structural and functional analysis of the GLT-1/EAAT-2 promoter from man and rat. Allritz C, et al. J Neurosci Res, 2010 May 1. PMID 19998491.
Clonality	Monoclonal
Gene ID	6506
Gene Name	SLC1A2
Subtitle	Mouse monoclonal antibody raised against a partial recombinant SLC1A2.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (34.54 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	SLC1A2 monoclonal antibody (M07), clone 1D8. Western Blot analysis of SLC1A2 expression in HeLa ( (Cat # AT3905a )
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Detection limit for recombinant GST tagged SLC1A2 is approximately 0.03ng/ml as a capture antibody.
Type image 3	E
Other Accession	NM_004171
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	SLC1A2 (NP_004162, 160 a.a. ~ 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001182657.1; NP_001239581.1; NP_004162.2
	Clone: 1D8
Org Accession	NP_004162
Concentration	1mg/ml
Gene Description	solute carrier family 1 (glial high affinity glutamate transporter), member 2
Gene Summary	This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 100 ug

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