Item no. |
ABC-AT3890a |
Manufacturer |
Abcepta
|
Amount |
100 ug |
Category |
|
Type |
Antibody Primary |
Format |
Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Applications |
WB, ELISA |
Clone |
7C2 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
SIRT1, SIR2L1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, 75SirT1, SirtT1 75 kDa fragment, 351- |
Available |
|
Primary Accession |
Q96EB6 |
Antigen Type |
Recombinant Protein |
Application |
WB, E |
Bio Background |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. |
Bio References |
SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Fan W, et al. Mol Cell, 2010 Jul 30. PMID 20670893.SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. Satoh A, et al. J Neurosci, 2010 Jul 28. PMID 20668205.SIRT1 variants are associated with aging in a healthy Han Chinese population. Zhang WG, et al. Clin Chim Acta, 2010 Nov 11. PMID 20633545.Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Calvanese V, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20631301.MicroRNA-34a regulation of endothelial senescence. Ito T, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20627091. |
Clonality |
Monoclonal |
Gene ID |
23411 |
Gene Name |
|
Subtitle |
Mouse monoclonal antibody raised against a partial recombinant SIRT1. |
Reactivity |
H |
Legend image 1 |
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . |
Type image 1 |
WB |
Dilution image 1 |
1:500~1000 |
Legend image 2 |
SIRT1 monoclonal antibody (M03), clone 7C2. Western Blot analysis of SIRT1 expression in Hela S3 NE ( (Cat # AT3890a ) |
Type image 2 |
WB |
Dilution image 2 |
1:500~1000 |
Legend image 3 |
Detection limit for recombinant GST tagged SIRT1 is 0.1 ng/ml as a capture antibody. |
Type image 3 |
E |
Other Accession |
BC012499 |
Isotype |
IgG1 Kappa |
Antigen Source |
Human: ~~ Positive |
Target/Specificity |
SIRT1 (AAH12499, 456 a.a. ~ 555 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
NCBI Accession |
NP_001135970.1; NP_036370.2 |
|
Clone: 7C2 |
Org Accession |
AAH12499 |
Gene Description |
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
Gene Summary |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.