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SERPING1 Antibody (monoclonal) (M01)

SERPING1 Antibody (monoclonal) (M01)

Item no.	ABC-AT3826a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, IP, IHC, ELISA
Clone	3F4-1D9
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SERPING1, C1IN, C1NH, C1 esterase inhibitor, C1-inhibiting factor, C1Inh, Plasma protease C1 inhibitor, Serpin G1, C1 Inh
Available
Primary Accession	P05155
Antigen Type	Recombinant Protein
Application	WB, IHC, IP, E
Bio Background	This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
Bio References	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Lee AY, et al. Br J Ophthalmol, 2010 Jul. PMID 20606025.Determination of a gene and environment risk model for age-related macular degeneration. Gibson J, et al. Br J Ophthalmol, 2010 Jun 24. PMID 20576771.Polymorphisms in innate immunity genes and risk of childhood leukemia. Han S, et al. Hum Immunol, 2010 Jul. PMID 20438785.Risk of meningioma and common variation in genes related to innate immunity. Rajaraman P, et al. Cancer Epidemiol Biomarkers Prev, 2010 May. PMID 20406964.
Clonality	Monoclonal
Gene ID	710
Gene Name	SERPING1
Subtitle	Mouse monoclonal antibody raised against a full length recombinant SERPING1.
Reactivity	H
Legend image 1	Immunoprecipitation of SERPING1 transfected lysate using anti-SERPING1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with SERPING1 MaxPab rabbit polyclonal antibody.
Type image 1	IP
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (80.52 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	SERPING1 monoclonal antibody (M01), clone 3F4-1D9. Western Blot analysis of SERPING1 expression in human liver.
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western Blot analysis of SERPING1 expression in transfected 293T cell line by SERPING1 monoclonal antibody (M01), clone 3F4-1D9. Lane 1: SERPING1 transfected lysate (Predicted MW: 55.2 KDa). Lane 2: Non-transfected lysate.
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Immunoperoxidase of monoclonal antibody to SERPING1 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 1 ug/ml]
Type image 5	IHC
Legend image 6	Detection limit for recombinant GST tagged SERPING1 is approximately 0.1ng/ml as a capture antibody.
Type image 6	E
Other Accession	BC011171
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	SERPING1 (AAH11171, 1 a.a. ~ 500 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_000053.2; NP_001027466.1
	Clone: 3F4-1D9
Org Accession	AAH11171
Gene Description	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Gene Summary	This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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