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S100A7 Antibody (monoclonal) (M02)

S100A7 Antibody (monoclonal) (M02)

Item no.	ABC-AT3761a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, IF, ELISA
Clone	1A4
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	S100A7, PSOR1, S100A7C, Protein S100-A7, Psoriasin, S100 calcium-binding protein A7
Available
Primary Accession	P31151
Antigen Type	Recombinant Protein
Application	WB, IF, E
Bio Background	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
Bio References	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. Tieu DD, et al. J Allergy Clin Immunol, 2010 Mar. PMID 20226301.S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer. West NR, et al. Oncogene, 2010 Apr 8. PMID 20101226.Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding. West NR, et al. Protein Sci, 2009 Dec. PMID 19844956.Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways. Le?n R, et al. Biochemistry, 2009 Nov 10. PMID 19810752.
Clonality	Monoclonal
Gene ID	6278
Gene Name	S100A7
Subtitle	Mouse monoclonal antibody raised against a full-length recombinant S100A7.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to S100A7 on A-431 cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.85 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	S100A7 monoclonal antibody (M02), clone 1A4 Western Blot analysis of S100A7 expression in A-431 ( (Cat # AT3761a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western Blot analysis of S100A7 expression in transfected 293T cell line by S100A7 monoclonal antibody (M02), clone 1A4. Lane 1: S100A7 transfected lysate(11.457 KDa). Lane 2: Non-transfected lysate.
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Detection limit for recombinant GST tagged S100A7 is approximately 10ng/ml as a capture antibody.
Type image 5	E
Other Accession	BC034687.1
Isotype	IgG1 Kappa
Target/Specificity	S100A7 (AAH34687.1, 1 a.a. ~ 101 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_002954.2
	Clone: 1A4
Org Accession	AAH34687.1
Concentration	1 mg/ml
Gene Description	S100 calcium binding protein A7
Gene Summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq

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Amount: 100 ug

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Delivery expected until 9/6/2024