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PLA2G4A Antibody (monoclonal) (M01)

PLA2G4A Antibody (monoclonal) (M01)

Item no.	ABC-AT3330a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, ELISA
Clone	10G5
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	cPLA2, PLA2G4A, CPLA2, PLA2G4, Phospholipase A2, Cytosolic phospholipase A2, Phospholipase A2 group IVA, Lysophospholipase, Phosphatidylcholine 2-acylhydrolase
Available
Primary Accession	P47712
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Bio References	Association Study of Interferon-gamma, Cytosolic Phospholipase A2, and Cyclooxygenase-2 Gene Polymorphisms in Alzheimer Disease. Feh?r A, et al. Am J Geriatr Psychiatry, 2010 Jun 30. PMID 20808133.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease. Cordeiro Q, et al. Arq Neuropsiquiatr, 2010 Apr. PMID 20464283.Cytosolic phospholipase A2 group IVA is overexpressed in patients with persistent asthma and regulated by the promoter microsatellites. Sokolowska M, et al. J Allergy Clin Immunol, 2010 Jun. PMID 20392485.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Clonality	Monoclonal
Gene ID	5321
Gene Name	PLA2G4A
Subtitle	Mouse monoclonal antibody raised against a partial recombinant PLA2G4A.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	Detection limit for recombinant GST tagged PLA2G4A is approximately 0.3ng/ml as a capture antibody.
Type image 2	E
Other Accession	NM_024420
Isotype	IgG1 Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	PLA2G4A (NP_077734, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_077734.1
	Clone: 10G5
Org Accession	NP_077734
Gene Description	phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene Summary	This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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