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FCER1A Antibody (monoclonal) (M01)

FCER1A Antibody (monoclonal) (M01)

Item no.	ABC-AT2024a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, ELISA
Clone	2C12-3B6
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	FCER1A, FCE1A, FcERI, Fc-epsilon RI-alpha, High affinity immunoglobulin epsilon receptor subunit alpha, IgE Fc receptor subunit alpha
Available
Primary Accession	P12319
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.
Bio References	Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism. Beckers MM, et al. Eur J Intern Med, 2010 Aug. PMID 20603037.Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. Kitahata Y, et al. Int Arch Allergy Immunol, 2010. PMID 20523060.Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.Polymorphisms in innate immunity genes and risk of childhood leukemia. Han S, et al. Hum Immunol, 2010 Jul. PMID 20438785.Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. Gill MA, et al. J Immunol, 2010 Jun 1. PMID 20410486.
Clonality	Monoclonal
Gene ID	2205
Gene Name	FCER1A
Subtitle	Mouse monoclonal antibody raised against a full length recombinant FCER1A.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (54.01 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	FCER1A monoclonal antibody (M01), clone 2C12-3B6 Western Blot analysis of FCER1A expression in A-549 ( (Cat # AT2024a )
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Western Blot analysis of FCER1A expression in transfected 293T cell line by FCER1A monoclonal antibody (M01), clone 2C12-3B6. Lane 1: FCER1A transfected lysate(29.6 KDa). Lane 2: Non-transfected lysate.
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western blot analysis of FCER1A over-expressed 293 cell line, cotransfected with FCER1A Validated Chimera RNAi ( (Cat # AT2024a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Detection limit for recombinant GST tagged FCER1A is 1 ng/ml as a capture antibody.
Type image 5	E
Other Accession	BC005912
Isotype	IgG1 Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	FCER1A (AAH05912.1, 1 a.a. ~ 257 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001992.1
	Clone: 2C12-3B6
Org Accession	AAH05912.1
Gene Description	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Gene Summary	The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM

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Amount: 100 ug

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Delivery expected until 9/6/2024