CRSP7 Antibody (monoclonal) (M06)

O95402

WB, IHC

MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. Ding N, et al. J Biol Chem, 2009 Jan 30. PMID 19049968.Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Zhang X, et al. Mol Cell, 2005 Jul 1. PMID 15989967.A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Sato S, et al. Mol Cell, 2004 Jun 4. PMID 15175163.Ras induces mediator complex exchange on C/EBP beta. Mo X, et al. Mol Cell, 2004 Jan 30. PMID 14759369.

9441

Mouse monoclonal antibody raised against a partial recombinant CRSP7.

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .

1:500~1000

WB

Immunoperoxidase of monoclonal antibody to MED26 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5 ug/ml]

NM_004831

Human: ~~ Positive

NP_004822.2

NP_004822

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq