Item no. |
ABC-ASC12171 |
Manufacturer |
Abcepta
|
Amount |
0.1 mg |
Category |
|
Type |
Antibody Primary |
Applications |
WB, IF, ICC, ELISA, IHC-P |
Clone |
CD276 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
CD276, B7H3, 4Ig-B7-H3, B7RP-2, B7-H3 Antibody: CD276 molecule |
Available |
|
Primary Accession |
Q5ZPR3 |
Application |
WB, IHC-P, IF, ICC, E |
Bio Background |
CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers. |
Bio References |
Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2:269-74.Sun M, Richards S, Prasad DV, et al. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168:6294-7.Yi KH and Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 2009; 229:145-51.Wang L, Kang FB, and Shan BE. B7-H3-mediated tumor immunology: friend or foe?. Int J Cancer 2014; 134:2764-71. |
Clonality |
Monoclonal |
Gene ID |
80381 |
Gene Name |
CD276 |
Other Accession |
NP_001019907 |
Isotype |
IgG1, k |
Calculated MW |
57235 |
|
Clone: CD276 |
Purification |
B7-H3 Antibody is supplied as protein A purified IgG1. |
Reconstitution & Storage |
B7-H3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Positive Control |
Cat. No. 1210 - HEK293 Cell Lysate; Cat. No. 17-010 - HEK293 Cell Slide; |
Buffer |
B7-H3 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.