Item no. |
ABC-ASC12122 |
Manufacturer |
Abcepta
|
Amount |
0.1 mg |
Category |
|
Type |
Antibody Primary |
Applications |
WB, IF, IHC, ICC, ELISA |
Clone |
VSIR |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
C10orf54, GI24, PP2135, SISP1, B7-H5, VISTA, B7H5, DD1alpha, PD-1H, V-set immunoregulatory receptor, VSIR, VISTA Antibody: VISTA molecule, chromosome 10 open reading frame 54, V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation, Chromosome 10 Open Reading Frame 54 |
Available |
|
Primary Accession |
Q9H7M9 |
Application |
WB, IHC, IF, ICC, E |
Bio Background |
The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5). |
Bio References |
Mayya V., et al . Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. 2009, Sci. Signal. 2:RA46-RA46.Sakr M.A., et al., GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. 2010, Cancer Sci. 101:2368-2374. |
Clonality |
Polyclonal |
Gene ID |
64115 |
Gene Name |
|
Other Accession |
NP_071436 |
Isotype |
IgG |
Calculated MW |
33908 |
|
Clone: VSIR |
Purification |
VISTA Antibody is affinity chromatography purified via peptide column. |
Reconstitution & Storage |
VISTA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Positive Control |
Cat. No. 11-533 - Human Tonsil Tissue Slide; |
Buffer |
VISTA Antibody is supplied in PBS containing 0.02% sodium azide. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.