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DTX4 Antibody

DTX4 Antibody

Item no.	ABC-ASC11879
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Primary Accession	Q9Y2E6
Application	WB, IHC-P, IF, E
Bio Background	The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2).
Bio References	Kishi N, Tang Z, Maeda Y, et al. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int. J. Dev. Neurosci. 2001; 19:21-35. Cui J, Li Y, Zhu L, et al. NLRP4 negatively regulated type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat. Immunol. 2012; 13:387-95.
Clonality	Polyclonal
Gene ID	23220
Gene Name	DTX4
Reactivity	H, M
Legend image 1	Western blot analysis of DTX4 in HeLa cell lysate with DTX4 antibody at 1 µg/ml.
Type image 1	WB
Legend image 2	Immunohistochemistry of DTX4 in human spleen tissue with DTX4 antibody at 5 µg/ml.
Type image 2	IHC
Legend image 3	Immunofluorescence of DTX4 in human spleen tissue with DTX4 antibody at 20 µg/ml.
Type image 3	IF
Other Accession	NP_055992; 148237498
Isotype	IgG
Calculated MW	67258
Antigen Source	homo sapiens
Target/Specificity	DTX4; DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.
Purification	DTX4 antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	DTX4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form	Liquid
Application Notes	DTX4 antibody can be used for detection of DTX4 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	HeLa Cell Lysate;
Buffer	DTX4 antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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