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SPINSTER Antibody

SPINSTER Antibody

Item no.	ABC-ASC11751
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Primary Accession	Q9H2V7
Application	WB, E
Bio Background	SPINSTER, also known as SPNS1 or SPIN1, is a 528 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and belongs to the spinster subfamily of the major facilitator superfamily (1). SPINSTER interacts with Bcl-x and Bcl-2 and, via this interaction, is thought to be involved in necrotic or autophagic cell death (2). The related protein SPNS2 is critical for the normal lymphocyte localization and mammalian immune system function (1, 3).
Bio References	Saier MH Jr, Beatty JT, Goffeau A, et al. The major facilitator superfamily. J. Mol. Microbiol. Biotechnol. 1999; 1:257-79. Yanagisawa H, Miyashita T, Nakano Y, et al. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ. 2003; 10:798-807. Nakano Y, Fujitani K, Kurihara J, et al. Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. Mol. Cell. Biol. 2001; 21:3775-88.
Clonality	Polyclonal
Gene ID	83985
Gene Name	SPNS1
Reactivity	H
Legend image 1	Western blot analysis of SPINSTER in human placenta tissue lysate with SPINSTER antibody at (A) 1 and (B) 2 µg/ml.
Type image 1	WB
Other Accession	NP_001135920; 215490098
Isotype	IgG
Calculated MW	56630
Antigen Source	homo sapiens
Target/Specificity	SPNS1; SPINSTER antibody is human specific. At least four isoforms of SPINSTER are known to exist. This antibody is predicted to not cross-react with other members of the spinster family of proteins.
Purification	SPINSTER antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	SPINSTER antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form	Liquid
Application Notes	SPINSTER antibody can be used for detection of SPINSTER by Western blot at 1 - 2 µg/ml.
Positive Control	Human Placenta Tissue Lysate;
Buffer	SPINSTER antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/4/2024

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