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GLIPR1L2 Antibody

GLIPR1L2 Antibody

Manufacturer	Abcepta
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Specific against	other
Applications	WB, IF, ELISA, IHC-P
Amount	100 ug
Host	Rabbit
Item no.	ABC-ASC11745
eClass 6.1	32160702
eClass 9.0	32160702
Available
Primary Accession	Q4G1C9
Application	WB, IHC-P, IF, E
Bio Background	The GLIPR1-like 2 protein (GLIPR1L2) gene is part of a p53 target gene cluster that includes the related proteins GLIPR1 and GLIPR1L2 (2). GLIPR1L2 is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (1). GLIPR1 is a tumor suppressor whose expression is regulated by p53 (3). Deletions of the GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster have been observed in some multiple myeloma samples, suggesting that these proteins may also be involved in the pathogenesis of multiple myeloma (4).
Bio References	Ren C, Ren CH, Li L, et al. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics 2006; 88:163-72. Murphy EV, Zhang Y, Zhu W, et al. The human glioma pathogenesis-related protein is structurally related to pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene 1995; 159:131-5. Ren C, Li L, Yang G, et al. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res. 2004; 64:969-76. Tam M, Lin P, Hu P, et al. Examining hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in situ hibridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients with multiple myeloma. J. Assoc. Genet. Technol. 2010; 36:111-4.
Clonality	Polyclonal
Gene ID	144321
Gene Name	GLIPR1L2
Reactivity	H
Legend image 1	Western blot analysis of GLIPR1L2 in human testis tissue lysate with GLIPR1L2 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Type image 1	WB
Legend image 2	Immunohistochemistry of GLIPR1L2 in human testis tissue with GLIPR1L2 antibody at 5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of GLIPR1L2 in human testis tissue with GLIPR1L2 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_001257325; 394025727
Isotype	IgG
Calculated MW	40179
Antigen Source	homo sapiens
Target/Specificity	GLIPR1L2; GLIPR1L2 antibody is human specific. At least two isoforms of GLIPR1L2 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.
Purification	GLIPR1L2 antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	GLIPR1L2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form	Liquid
Application Notes	GLIPR1L2 antibody can be used for detection of GLIPR1L2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Human Testis Tissue Lysate;
Buffer	GLIPR1L2 antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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