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TMEM106B Antibody

TMEM106B Antibody

Item no.	ABC-ASC11462
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Primary Accession	Q9NUM4
Application	WB, IHC-P, IF, E
Bio Background	TMEM106B Antibody: Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.
Bio References	Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9. Aswathy PM, Jairani PS, and Mathuranath PS. Genetics of frontotemporal lobar degeneration. Ann. Indian Acad. Neurol. 2010; 13(Suppl 2):S55-62.
Clonality	Polyclonal
Gene ID	54664
Gene Name	TMEM106B
Reactivity	H
Legend image 1	Western blot analysis of TMEM106B in human brain tissue lysate with TMEM106B antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Type image 1	WB
Legend image 2	Immunohistochemistry of TMEM106B in human liver tissue with TMEM106B antibody at 2.5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of TMEM106B in human liver tissue with TMEM106A antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_060844; 40254893
Isotype	IgG
Calculated MW	31127
Antigen Source	Homo sapiens
Target/Specificity	TMEM106B; This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A.
Purification	TMEM106B Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	TMEM106B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	TMEM106B antibody can be used for detection of TMEM106B by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.
Positive Control	Human Brain Tissue Lysate;
Buffer	TMEM106B Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/4/2024

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