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PLAC3 Antibody

PLAC3 Antibody

Item no.	ABC-ASC11221
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IF, ICC, ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Primary Accession	Q9BXP8
Application	WB, IF, ICC, E
Bio Background	PLAC3 Antibody: PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
Bio References	Overgaard MT, Boldt HB, Laursen LS, et al. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase. J. Biol. Chem.2001; 276:1849-53. Wang J, Qiu Q, Haider M, et al. Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse. J. Endocrin.2009; 202:337-45. Nishizawa H, Pryor-Koishi K, Suzuki M, et al. Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients. Mol. Hum. Reprod.2008; 14:595-602. Buimer M, Keijser R, Jebbink JM, et al. Seven placental transcripts characterize HELLP syndrome. Placenta2008; 29:444-53.
Clonality	Polyclonal
Gene ID	60676
Gene Name	PAPPA2
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of PLAC3 in HeLa cell lysate with PLAC3 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Type image 1	WB
Legend image 2	Immunocytochemistry of PLAC3 in HeLa cells with PLAC3 antibody at 10 µg/mL.
Type image 2	ICC
Legend image 3	Immunofluorescence of PLAC3 in HeLa cells with PLAC3 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_064714; 116174738
Isotype	IgG
Calculated MW	198539
Antigen Source	Homo sapiens
Target/Specificity	PAPPA2;
Purification	PLAC3 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	PLAC3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	PLAC3 antibody can be used for detection of PLAC3 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	HeLa Cell Lysate;
Buffer	PLAC3 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 11/8/2024

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