PALB2 Antibody

Q86YC2

PALB2 Antibody: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.

Polyclonal

PALB2

Western blot analysis of PALB2 in SK-N-SH cell lysate with PALB2 antibody at 1 µg/mL.

Q86YC2; 74727919

131295

PALB2; At least four isoforms of PALB2 are known to exist; this antibody will detect all four isoforms.

PALB2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

PALB2 antibody can be used for detection of PALB2 by Western blot at 1 - 2 µg/mL.

PALB2 Antibody is supplied in PBS containing 0.02% sodium azide.