Item no. |
ABC-ASC10861 |
Manufacturer |
Abcepta
|
Amount |
100 ug |
Category |
|
Type |
Antibody Primary |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Available |
|
Primary Accession |
Q791V5 |
Application |
WB, IHC-P, IF, E |
Bio Background |
MTCH2 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway. |
Bio References |
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ.2000; 7:2-7.Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene2003; 22:8590-607.Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron.2004; 39:1125-35.Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol.2005; 25:4579-90. |
Clonality |
Polyclonal |
Gene ID |
56428 |
Gene Name |
Mtch2 |
Reactivity |
H, M |
Legend image 1 |
Western blot analysis of MTCH2 in 293 cell lysate with MTCH2 antibody at 1 µg/mL. |
Type image 1 |
WB |
Legend image 2 |
Immunohistochemistry of MTCH2 in mouse kidney tissue with MTCH2 antibody at 5 µg/mL. |
Type image 2 |
IHC |
Legend image 3 |
Immunofluorescence of MTCH2 in Mouse Kidney cells with MTCH2 antibody at 20 µg/mL. |
Type image 3 |
IF |
Other Accession |
NP_055157; 5815347 |
Isotype |
IgG |
Calculated MW |
33499 |
Antigen Source |
Mus musculus |
Target/Specificity |
Mtch2; |
Purification |
MTCH2 Antibody is affinity chromatography purified via peptide column. |
Reconstitution & Storage |
MTCH2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Antibody Form |
Liquid |
Application Notes |
MTCH2 antibody can be used for detection of MTCH2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
Positive Control |
293 Cell Lysate; |
Buffer |
MTCH2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.