APH1 Antibody

Q96BI3

APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.

Polyclonal

APH1A

Western blot analysis of APH1 in human brain tissue lysate with APH1 antibody at (A) 0.5 and (B) 1 µg/mL.

Immunohistochemistry of APH1 in human brain tissue with APH1 antibody at 5 µg/mL.

AAH08732; 14250557

28996

APH1A;

APH1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

APH1 antibody can be used for detection of APH1 by Western blot at 0.5 - 1 µg/mL. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.

APH1 Antibody is supplied in PBS containing 0.02% sodium azide.