Item no. |
ABC-ASC10409 |
Manufacturer |
Abcepta
|
Amount |
100 ug |
Category |
|
Type |
Antibody Primary |
Applications |
WB, IF, ICC, ELISA |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
tumor necrosis factor receptor superfamily, ATAR, HVEA, HVEM, LIGHTR, Tumor necrosis factor receptor superfamily member 14, Herpesvirus entry mediator A, CD270, Herpes virus entry mediator A, TNFRSF14 Antibody: TR2, UNQ329/PRO509, member 14 (herpesvirus entry mediator) |
Available |
|
Primary Accession |
Q92956 |
Application |
WB, IF, ICC, E |
Bio Background |
TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κ B and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. |
Bio References |
Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 2005; 23:23-68.Montgomery RI, Warner MS, Lum BJ, et al. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 1996; 87:427-36.Marsters SA, Ayres TM, Skubatch M, et al. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-κB and AP-1. J. Biol. Chem.1997; 272:14029-32.Mauri DN, Ebner R, Montgomery RI, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 1998; 8:21-30. |
Clonality |
Polyclonal |
Gene ID |
8764 |
Gene Name |
|
Reactivity |
H |
Legend image 1 |
Western blot analysis of BICD2 in 293 cell lysate with BICD2 antibody at (A) 1 and (B) 2 µg/mL. |
Type image 1 |
WB |
Other Accession |
Q92956; 8764 |
Isotype |
IgG |
Calculated MW |
30392 |
Antigen Source |
Homo sapiens |
Target/Specificity |
TNFRSF14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human TNFRSF14.
The immunogen is located within the last 50 amino acids of TNFRSF14. |
Purification |
TNFRSF14 Antibody is affinity chromatography purified via peptide column. |
Reconstitution & Storage |
TNFRSF14 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Antibody Form |
Liquid |
Application Notes |
TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 2 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL. For immunofluorescence start at 20 μ g/mL. |
Positive Control |
Raji Cell Lysate; |
Buffer |
TNFRSF14 Antibody is supplied in PBS containing 0.02% sodium azide. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.