Item no. |
ABC-ASC10263 |
Manufacturer |
Abcepta
|
Amount |
100 ug |
Category |
|
Type |
Antibody Primary |
Applications |
WB, ELISA |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
UEV1A, CROC1, UBE2V, UEV1, Ubiquitin-conjugating enzyme E2 variant 1, CROC-1, ubiquitin-conjugating enzyme E2 variant 1, UEV-1, UEV1A Antibody: CIR1, P/OKcl.19 |
Available |
|
Primary Accession |
Q13404 |
Application |
WB, E |
Bio Background |
UEV1A Antibody: Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation. |
Bio References |
Sancho E, Vila MR, Sanchez-Pulido L, et al. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Mol. Cell Biol. 1998; 18:576-89.Akira S and Takeda K. Toll-like receptor Signalling. Nat. Rev. Immunol. 2004; 4:499-511.Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.Deng L, Wang C, Spencer E, et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000; 103:351-61. |
Clonality |
Polyclonal |
Gene ID |
387522; 7335 |
Gene Name |
UBE2V1 |
Reactivity |
H, M, Rat |
Legend image 1 |
Western blot analysis of UEV1A in Jurkat cell lysates with UEV1A antibody at (A) 1, (B) 2, and (C) 4 µg/mL. |
Type image 1 |
WB |
Other Accession |
NP_954595; 40806167 |
Isotype |
IgG |
Calculated MW |
16495 |
Antigen Source |
Homo sapiens |
Target/Specificity |
UBE2V1; Anti-UEV1A may also recognize other isoforms of UEV1A. |
Purification |
UEV1A Antibody is Ion exchange chromatography purified. |
Reconstitution & Storage |
UEV1A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Antibody Form |
Liquid |
Application Notes |
UEV1A antibody can be used for detection of UEV1A by Western blot at 1 to 4 µg/mL. |
Positive Control |
Jurkat Cell Lysate; |
Buffer |
UEV1A Antibody is supplied in PBS containing 0.02% sodium azide. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.