Survivin Antibody

O15392

Survivin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.

Polyclonal

BIRC5

Immunohistochemistry of Adiponectin in mouse brain tissue with Adiponectin antibody at 5 µg/ml.

Immunohistochemistry of XIAP in mouse kidney tissue with XIAP antibody at 5 µg/mL.

NP_001159; 332

16389

Survivin antibody was raised against a peptide corresponding to 12 amino acids near the amino terminus of human survivin.

The immunogen is located within the first 50 amino acids of Survivin.

Survivin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Survivin antibody can be used for detection of survivin by Western blot at 1 - 2 μ g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL and immunocytochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.

Survivin Antibody is supplied in PBS containing 0.02% sodium azide.