Item no. |
ABC-AP9673B-ev-80ul |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Western Blot |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CYTH3, ARNO3, GRP1, PSCD3 |
Available |
|
Primary Accession |
O43739 |
Other Accession |
P97696; O08967 |
Antigen Type |
Synthetic Peptide |
Bio Background |
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. |
Bio References |
Morishige, M., et al. Nat. Cell Biol. 10(1):85-92(2008) Poirier, M.B., et al. Mol. Endocrinol. 19(8):1991-2005(2005) Nevrivy, D.J., et al. J. Biol. Chem. 275(22):16827-16836(2000) Ogasawara, M., et al. J. Biol. Chem. 275(5):3221-3230(2000) |
Gene ID |
9265 |
Gene Name |
|
Reactivity |
H, M |
Predicted |
Rat |
Calculated MW |
46349 |
Antigen Region |
371-400 |
Antigen Source |
HUMAN |
Target/Specificity |
This CYTH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-400 amino acids from the C-terminal region of human CYTH3. |
NCBI Accession |
NP_004218.1 |
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