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LFNG Antibody (Center)

LFNG Antibody (Center)

Item no.	ABC-AP9524c-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, FC, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	LFNG, Beta-1, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, 3-N-acetylglucosaminyltransferase lunatic fringe
Available
Primary Accession	Q8NES3
Antigen Type	Synthetic Peptide
Application	FC, IHC-P, WB
Bio Background	LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1, 3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150).
Bio References	Dunwoodie, S.L. Biochim. Biophys. Acta 1792(2):100-111(2009) Reedijk, M., et al. Int. J. Oncol. 33(6):1223-1229(2008) Sparrow, D.B., et al. Am. J. Hum. Genet. 78(1):28-37(2006) Cole, S.E., et al. Dev. Cell 3(1):75-84(2002) Moran, J.L., et al. Mamm. Genome 10(6):535-541(1999)
Clonality	Polyclonal
Clone/Animal Names	RB24078
Gene ID	3955
Gene Name	LFNG
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	LFNG Antibody (Center) (Cat. #AP9524c) western blot analysis in HL-60, K562, Hela cell line lysates (35ug/lane).This demonstrates the LFNG antibody detected the LFNG protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	LFNG Antibody (Center)(Cat. #AP9524c) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LFNG Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	LFNG Antibody (Center) (Cat. #AP9524c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Isotype	Rabbit Ig
Calculated MW	41773
Antigen Region	86-114
Antigen Source	HUMAN
Target/Specificity	This LFNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human LFNG.
NCBI Accession	NP_001035257.1; NP_001035258.1; NP_001159827.1; NP_002295.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 10/4/2024

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