Bio Background |
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. |
Bio References |
Musayev, F.N., et al. J. Biol. Chem. 284(45):30949-30956(2009)Khayat, M., et al. Mol. Genet. Metab. 94(4):431-434(2008)Song, H., et al. Schizophr. Res. 97 (1-3), 264-270 (2007) :Mills, P.B., et al. Hum. Mol. Genet. 14(8):1077-1086(2005)Kang, J.H., et al. Eur. J. Biochem. 271(12):2452-2461(2004)Musayev, F.N., et al. Protein Sci. 12(7):1455-1463(2003) |