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BAT1 Antibody (C-term)

BAT1 Antibody (C-term)

Item no.	ABC-AP8740b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Flow cytometry, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Spliceosome RNA helicase DDX39B, 56 kDa U2AF65-associated protein, ATP-dependent RNA helicase p47, DEAD box protein UAP56, HLA-B-associated transcript 1 protein, DDX39B, BAT1, UAP56
Available
Primary Accession	Q13838
Other Accession	Q63413; Q29024; Q9Z1N5; Q27268; Q5ZHZ0; Q3T147; Q5U216; Q8VDW0; O00148
Antigen Type	Synthetic Peptide
Bio Background	Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4. Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. It has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. It can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. It can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2 and THOC4.
Bio References	Choudhary C., et.al., Science 325:834-840(2009). Boyne J.R., et.al., PLoS Pathog. 4:E1000194-E1000194(2008).
Gene ID	7919
Gene Name	DDX39B
Reactivity	H
Predicted	M, Rat, B, C, D, Pig
Calculated MW	48991
Antigen Region	351-380
Antigen Source	HUMAN
Target/Specificity	This BAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human BAT1.
NCBI Accession	NP_004631.1; NP_542165.1

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Amount: 80 ul

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