Bio Background |
ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1, 4, 5-trisphosphate to Ins(1, 3, 4, 5)P4. The activity of the inositol 1, 4, 5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region. |
Bio References |
Gonzalez, B., et al., Mol. Cell 15(5):689-701 (2004). Mishra, J., et al., Biophys. J. 83(3):1298-1316 (2002). Schell, M.J., et al., J. Biol. Chem. 276(40):37537-37546 (2001). Communi, D., et al., EMBO J. 16(8):1943-1952 (1997). Woodring, P.J., et al., J. Biol. Chem. 272(48):30447-30454 (1997). |