Item no. |
ABC-AP8146a |
Manufacturer |
Abcepta
|
Amount |
400 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Applications |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
Fructose-2, 6-phosphofructo-2-kinase/fructose-2, 6PF-2-K/Fru-2, 6-phosphofructo-2-kinase, 6-bisphosphatase, PFKFB2, 6-bisphosphatase 2, 6-P2ase heart-type isozyme, 6-P2ase 2, PFK/FBPase 2 |
Available |
|
Primary Accession |
O60825 |
Antigen Type |
Synthetic Peptide |
Application |
IHC-P, WB |
Bio Background |
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). |
Bio References |
Soejima, H., et al., Genomics 74(1):115-120 (2001).Heine-Suner, D., et al., Eur. J. Biochem. 254(1):103-110 (1998). |
Clonality |
Polyclonal |
Clone/Animal Names |
RB4031/4032 |
Gene ID |
5208 |
Gene Name |
PFKFB2 |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Western blot analysis of anti-PFKFB2 Pab (Cat. #AP8146a) in mouse kidney tissue lysate (35ug/lane). PFKFB2(arrow) was detected using the purified Pab |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:50~100 |
Isotype |
Rabbit Ig |
Calculated MW |
58477 |
Antigen Region |
1-30 |
Antigen Source |
HUMAN |
Target/Specificity |
This PFKFB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PFKFB2. |
NCBI Accession |
NP_001018063.1; NP_006203.2 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.