Manufacturer |
Abcepta
|
Category |
|
Type |
Antibody Primary |
Specific against |
other |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Applications |
WB |
Amount |
80 ul |
Host |
Rabbit |
Item no. |
ABC-AP7995a-ev |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Primary Accession |
P10632 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
CYP2C8 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. |
Bio References |
Adjei, G.O., Antimicrob. Agents Chemother. 52 (12), 4400-4406 (2008)Aquilante, C.L., Hum. Genomics 3 (1), 7-16 (2008)Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB17003 |
Gene ID |
1558 |
Gene Name |
CYP2C8 {ECO:0000303|PubMed:7574697, ECO:0000312|HGNC:HGNC:2622} |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Western blot analysis of anti-CYP2C8 Antibody (N-term) (Cat.#AP7995a) in T47D cell line lysates (35ug/lane). CYP2C8(arrow) was detected using the purified Pab. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Isotype |
Rabbit Ig |
Calculated MW |
55825 |
Antigen Region |
74-105 |
Antigen Source |
HUMAN |
Target/Specificity |
This CYP2C8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-105 amino acids from the N-terminal region of human CYP2C8. |
NCBI Accession |
NP_000761.3; NP_001185782.1; NP_001185783.1; NP_001185784.1 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.