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MAP2K1 Antibody (T291)

MAP2K1 Antibody (T291)

Item no.	ABC-AP7960e-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MAP2K1, MEK1, Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAPK/ERK kinase 1, PRKMK1, MKK1, MAP kinase kinase 1, MAPKK 1, MEK 1
Available
Primary Accession	Q02750
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Bio References	Zheng, B., et al., Blood 102(3):1019-1027 (2003). Li, S.P., et al., Cancer Res. 63(13):3473-3477 (2003). Zhu, X., et al., J. Neurochem. 86(1):136-142 (2003). Fringer, J., et al., J. Biol. Chem. 278(23):20612-20617 (2003). Witowsky, J.A., et al., J. Biol. Chem. 278(3):1403-1406 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB11151
Gene ID	5604
Gene Name	MAP2K1 (HGNC:6840)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	MAP2K1 Antibody (pT291) (Cat.# AP7960e) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MAP2K1 antibody detected the MAP2K1 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MAP2K1 Antibody (T291) (Cat.#AP7960e), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	Q01986; P29678; P31938; Q63980
Predicted	Ha, M, Rb, Rat
Isotype	Rabbit Ig
Calculated MW	43439
Antigen Region	270-299
Antigen Source	HUMAN
Target/Specificity	This MAP2K1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-299 amino acids from human MAP2K1.
NCBI Accession	NP_002746.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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