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RUNX2 Antibody (N-term)

RUNX2 Antibody (N-term)

Item no.	ABC-AP7735a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Neuroscience Neural Development Antibodies Hematology Leukemia Immunohistochemistry Primary Antibodies Heart & Blood Cancer
Type	Antibody Polyclonal
Applications	Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, CBF-alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, OSF-2, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEA2-alpha
Available
Primary Accession	Q13950
Antigen Type	Synthetic Peptide
Bio Background	Runx2 is a member of the RUNX family of transcription factors. It is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in the Runx2 gene have been associated with the bone development disorder cleidocranial dysplasia (CCD).
Bio References	Rich, J.T., Biochem. Biophys. Res. Commun. 372 (1), 230-235 (2008) Ermakov, S., Ann. Hum. Genet. 72 (PT 4), 510-518 (2008) Endo, T., J. Clin. Endocrinol. Metab. 93 (6), 2409-2412 (2008)
Gene ID	860
Gene Name	RUNX2
Reactivity	H
Calculated MW	56648
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This RUNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1ca.30 amino acids from the N-terminal region of human RUNX2.
NCBI Accession	NP_001015051.3; NP_001019801.3

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Amount: 80 ul

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