Item no. |
ABC-AP7563C-ev-80ul |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
Western Blot, Flow cytometry, Immunohistochemistry |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP3, CPP32 |
Available |
|
Primary Accession |
P42574 |
Antigen Type |
Synthetic Peptide |
Bio Background |
CASP3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. |
Bio References |
Wright, M.H., Biochem. Biophys. Res. Commun. 369 (2), 478-484 (2008) Brown, E.T., Radiat. Res. 169 (5), 595-601 (2008) Mustafa, T., Virchows Arch. 452 (4), 449-456 (2008) |
Gene ID |
836 |
Gene Name |
CASP3 |
Reactivity |
H |
Calculated MW |
31608 |
Antigen Region |
60-90 |
Antigen Source |
HUMAN |
Target/Specificity |
This Caspase-3 (CASP3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the Central region of human Caspase-3 (CASP3). |
NCBI Accession |
NP_004337.2; NP_116786.1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.