Alias |
Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19, STK11, LKB1, PJS |
Bio Background |
STK11, is a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. |
Bio References |
Mart, et al., J. Biotechnol. 115(1):23-34 (2005). Shaw, R.J., et al., Proc. Natl. Acad. Sci. U.S.A. 101(10):3329-3335 (2004). Suzuki, A., et al., Biochem. Biophys. Res. Commun. 324(3):986-992 (2004). Hearle, N., et al., Genes Chromosomes Cancer 41(2):163-169 (2004). Corradetti, M.N., et al., Genes Dev. 18(13):1533-1538 (2004). |