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HMGCR Antibody (Center)

HMGCR Antibody (Center)

Item no.	ABC-AP6577c
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase
Available
Primary Accession	P04035
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Bio References	Chen, Y.C., Lipids 44 (8), 733-743 (2009)
Clonality	Polyclonal
Clone/Animal Names	RB19370
Gene ID	3156
Gene Name	HMGCR (HGNC:5006)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of HMGCR antibody (Center) (Cat. #AP6577c) in Jurkat cell line lysates (35ug/lane). HMGCR (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	HMGCR Antibody (Center) (Cat. #AP6577c) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HMGCR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	97476
Antigen Region	380-410
Antigen Source	HUMAN
Target/Specificity	This HMGCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380~410 amino acids from the Center region of human HMGCR.
NCBI Accession	NP_000850.1; NP_001124468.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/8/2024

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