AF4 (MLLT2) Antibody (C-term)

Synthetic Peptide

MLLT2 is involved in acute leukemias through a chromosomal translocation t(4; 11)(q21; q23) that involves mllt2 and mll/hrx. AF-4 (MLLT2), AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis.

Polyclonal

4299

Purified Rabbit Polyclonal Antibody (Pab)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

1:50~100

Rabbit Ig

1181-1210

This AF4 (MLLT2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1181~1210 amino acids from the C-terminal region of human MLLT2.