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WDR77 Antibody

WDR77 Antibody

Item no.	ABC-AP52808
Manufacturer	Abcepta
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, ICC
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	2610312E17Rik;Androgen receptor cofactor p44;C79984;HKMT1069;MEP 50;MEP-50;MEP50; MEP50_HUMAN;Methylosome protein 50;MGC2722;Nbla10071;p44;p44/Mep50;RGD1310479;RP11 552M11.3;WD repeat containing protein 77;WD repeat domain 77;WD repeat-containing protein
Available
Primary Accession	Q9BQA1
Antigen Type	Recombinant Protein
Application	WB, ICC
Bio Background	Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Bio References	Friesen W.J., et al.J. Biol. Chem. 277:8243-8247(2002). Hosohata K., et al.Mol. Cell. Biol. 23:7019-7029(2003). Ota T., et al.Nat. Genet. 36:40-45(2004). Yamada S., et al.Oncogene 23:5901-5911(2004). Gregory S.G., et al.Nature 441:315-321(2006).
Clonality	Monoclonal
Gene ID	79084
Gene Name	WDR77
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H, M
Legend image 1	Western blot detection of WDR77 in C6, 3T3 and K562 cell lysates using WDR77 mouse mAb (1:1000 diluted).Predicted band size:42KDa.Observed band size:42KDa.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Immunocytochemistry staining of HeLa cells fixed in 1% Paraformaldehyde and then permeabilized in 0.1% Triton X-100, next using WDR77 mouse mAb (dilution 1:100).
Type image 2	ICC
Dilution image 2	1:100

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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