Item no. |
ABC-AP3902a-ev |
Manufacturer |
Abcepta
|
Amount |
80 ul |
Category |
|
Type |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applications |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
ERBB2, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, Tyrosine kinase-type cell surface receptor HER2, MLN 19, HER2, NEU, NGL, MLN19, Metastatic lymph node gene 19 protein, CD340 |
Available |
|
Primary Accession |
P04626 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
Bio References |
Ehsani A., et al. Genomics 15:426-429(1993).Yamamoto T., et al. Nature 319:230-234(1986).Coussens L., et al. Science 230:1132-1139(1985).Wakamatsu A., et al. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. |
Clonality |
Polyclonal |
Gene ID |
2064 |
Gene Name |
ERBB2 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Western blot analysis of extracts from A431 cells, untreated or treated with EGF, 100ng/ml,using phospho ErbB2-Y1222 (left) or ErbB2 antibody(right) |
Type image 1 |
WB |
Dilution image 1 |
1:5000 |
Isotype |
Rabbit Ig |
Calculated MW |
137910 |
Antigen Source |
Human |
Target/Specificity |
This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1222 of human ERBB2. |
NCBI Accession |
NP_001005862.1; NP_004439.2 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.